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| Title | Entropic barriers, transition states, funnels, and exponential protein folding kinetics: a simple model. |
| Author(s) | Bicout DJ, Szabo A. |
| ID# | 10752607 |
| Abstract | This paper presents an analytically tractable model that captures the most elementary aspect of the protein folding problem, namely that both the energy and the entropy decrease as a protein folds. In this model, the system diffuses within a sphere in the presence of an attractive spherically symmetric potential. The native state is represented by a small sphere in the center, and the remaining space is identified with unfolded states. The folding temperature, the time-dependence of the populations, and the relaxation rate are calculated, and the folding dynamics is analyzed for both golf-course and funnel-like energy landscapes. This simple model allows us to illustrate a surprising number of concepts including entropic barriers, transition states, funnels, and the origin of single exponential relaxation kinetics. |
| Publisher Link | http://onlinelibrary.wiley.com/doi/10.1110/ps.9.3.452/abstract |
| Full Text Link | pdf |
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